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This mechanism regulates epithelial cell polarization, which plays an important role to maintain physiological functions, such as tissue barrier and gas exchange in healthy epithelial cells

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While a study in chronic insomnia patients has reported that short-term DSIP administration is unlikely to be of major therapeutic benefit, a 16-month study in mice found that long-term DSIP administration increased maximum life span and decreased the rate of tumor growth [22, 23]

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