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Copper is a required cofactor for lysyl oxidase (connective-tissue crosslinking), for superoxide dismutase (antioxidant defense), and for enzymes that support angiogenesis, so a molecule that delivers copper in a controlled, cell-usable form has a coherent reason to influence tissue remodeling and vascular biology

However, direct cartilage injection of IGF-1 more effective than systemic elevation, and systemic growth hormone peptides produce modest IGF-1 increases (not pharmacological levels)

Dipeptides: These consist of three amino acid units connected by two peptide bonds