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RESULTS All of the NSAIDs induced both lower esophageal and pyloric sphincters pressure fall, and thereby the induced sphincter failure may be a common phenomenon of NSAIDs, with some particularities for the used non-specific (diclofenac, ibuprofen, aspirin, paracetamol) and specific (celecoxib) NSAIDs ( Figs

[9] At pH values between about 2.5 and 4.1, [9] the carboxylic acid closer to the amine generally loses a proton, and the acid becomes the neutral zwitterion OOCCH(NH + 3 )(CH 2 ) 2 COOH