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Macroscopically, a degenerated disc contains annulus fissures 8 , and/or endplate defects 9 , and microscopic changes include accelerated loss of water-retaining glycosaminoglycan (GAG) molecules 10 , nerve and blood vessel infiltration 11 , cell clustering 12 , and upregulation of matrix-degrading enzymes 13

This is a critical distinction between research evidence and regulatory approval, and it affects legal status, availability, and the framework within which these compounds can be used

The FDA could simply remove the peptides from Category 2, those it considers unsafe

Clinical Evidence Supporting PRP in Osteoarthritis PRP vs