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The intermittent treatment design follows preclinical evidence that demonstrated senescent cells require 2-4 weeks to develop and complete senescent cell clearance is not required for disease modifying effects

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Importantly, the MS research community could glean valuable concepts and borrow helpful techniques from the neurodegeneration field

In addition to dietary intake, malabsorption conditions like celiac disease, atrophic gastritis, and inflammatory bowel diseases, all of autoimmune nature and frequently associated with autoimmune thyroid diseases, must be taken into account when vitamin B12 requirements are evaluated [97,98,99]