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Here, airway epithelial cells cannot induce CHAC1 expression in response to bacterial or viral infection

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doi: 10.1016/j.intimp.2014.02.023 75 WeiZFTongBXiaYFLuQChouGXWangZTet al

The overall effects of these alterations are increased emotional hyperactivity (orbitofrontal and basolateral hyperactivity of the amygdala not moderated by the central amygdala equipped with a robust network of GABAergic neurons), memory lability (hippocampal hypotrophy), and cognitive and environmental self-regulation difficulties (mPFC and hippocampal hypotrophy and, consequently, of salience networks, which is based on these areas)