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Moreover, topical NSAIDs, especially topical diclofenac, are strongly recommended as first-line pharmacological therapy for patients with localized OA, particularly of the knee and hand, and in individuals for whom systemic NSAIDs pose unacceptable risk

The peptide counteracted picrotoxin (non-competitive GABA receptor Cl channel blocker), isoniazid (inhibitor of glutamic acid decarboxylase and GABA synthesis), and bicuculline (GABA-A antagonist), all through dose-dependent protective effects without producing behavioral changes when administered alone

These results suggested a possible progression from NAFLD to NASH due to oxidative stress and demonstrated a potential therapeutic role for GSH in controlling the progression of liver damage

Colonies were allowed to grow in drug-free medium for 7 days and stained with 0.5% crystal violet