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Gut dysbiosis associated with an increase toxins or substances permeability of LPS and therefore affects the Liver functions, which means these substances will remain in the blood, hence, reaching every single organ in the body including the hypothalamus

doi: 10.1016/j.biopha.2015.07.034, 56

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The Vitamin C often found in these supplements helps with the absorption and utilization of both ingredients, creating a synergistic effect for skin health and antioxidant support