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Finally, changes in the lipidomic profile of mitochondria membranes might compromise mitochondria permeabilization and cellular responses susceptible to neurodegeneration

The bioavailability differs, the dosing schedule changes from weekly to daily, and the evidence base is less robust

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The absence of conclusive results through human trials is partly why despite being proven to precede amyloid accumulation, oxidative stress has not received as much attention as amyloid plaques have traditionally and historically received for treating Alzheimer's disease