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Remyelination protects axons from demyelination-associated axon degeneration

The lack of a unified definition raises concerns about the generalizability of conclusions and represents an important area for methodological improvement in future research

Interestingly, astrocytes often do not transition into this more damaging/senescent-like state unless microglia induce the switch through the release of cytokines like IL-1 and TNF (Herx et al., 2000