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Br J Nutr 2015;114:831-4

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Further investigations revealed that sphingolipid metabolism in astrocytes stimulated inflammation within the CNS via the trigger mechanisms of cPLA2-MAVS protein interaction-enhanced NF-B signaling (57)

Lactate inhibits 2-oxoglutarate-dependent prolyl hydroxylases (PHDs) (mainly PHD2), which in turn prevents Von Hippel Lindau tumor suppressor (VHL)-mediated ubiquitination of hypoxia-inducible factor 1 (HIF-1) and its proteasomal degradation, thus stabilizing HIF-1