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In vitiligo patients, melanocytes are particularly sensitive to oxidative damage, which disrupts TYR function, inhibits eumelanin synthesis, and ultimately impairs pigmentation 46

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Additional factors which contribute to the formation of Meibomian gland obstructions include: -An accumulation, or buildup, of keratin (a protein) contributing to the narrowing or blocking of the Meibomian gland ducts -Dead skin (epithelial) cells or debris can accumulate and block the glands -Eye rubbing causing mechanical trauma and exacerbating inflammation

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