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With the exceptions of exotoxins secreted by enteropathogenic bacteria, such as the clostridial exotoxins or botulinum exotoxins discussed below, most endotoxins of commensal bacteria are not absorbed by the intact intestine of healthy individuals [49, 55]

Abstract The leakage of the intestinal barrier and the disruption of the gut microbiome are increasingly recognized as key factors in different pathophysiological conditions, such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), chronic liver diseases, obesity, diabetes mellitus, types of cancer, and neuropsychiatric disorders

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