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It is an essential nutrient involved in gene regulation, neurotransmitter production, homocysteine conversion, cognitive function and many other processes that support the body and mind

We employed selective inhibitors of different steps of the glutathione cycle and the glutamine-glutamate shuttle and show that glutathione serves as a source for a material portion of glutamatergic neurotransmission

Conversely, hypoxia and glucose deprivation in the brain promotes HDAC9 expression in endothelial cells, which has been associated to decreased expression of ZO-1, claudin-5, and occludin (Shi et al., 2016)