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The utilisation of omics approaches such as scRNAseq to delineate the specific effects of ROS modulation in individual cell types during different stages of wound healing and chronic wound pathogenesis would additionally be of benefit for this purpose

If the accumulation of hydrogen peroxide is not limited, it can diffuse to the cytosol or participate in a chain of reactions that generate more reactive free radicals, such as hydroxyl radical, which can oxidize mitochondrial components (proteins, lipids, and DNA)

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It is important to note that whilst B12 deficiency can cause nerve pain, not all nerve pain is caused by B12 deficiency