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Since vitamin B 12 is a determinant of homocysteine metabolism, it was suggested that the risk of osteoporotic fractures in older subjects might be enhanced by vitamin B 12 deficiency

For those without malabsorption issues, oral B12 supplements may be appropriate if dietary intake is insufficient

Food and Drug Administration (FDA) and applicable state pharmacy boards before initiating or modifying any compounding or dispensing program

There are specific scenarios where combining these two forms of B12 might be considered, as part of a tailored treatment plan: Reducing Injection Frequency: For some individuals who require lifelong B12 due to malabsorption but dislike frequent injections, a doctor might explore if high-dose oral supplements can help maintain adequate levels between less frequent injections