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This glycolytic exhaustion, intertwined with lipid toxicity, coalesces into a self-reinforcing metabolic vortex that etches both the penumbras fate and the patients long-term functional identity, directly linking metabolic collapse to neuropsychiatric sequelae like post-stroke depression and anxiety [19, 20]

were able to demonstrate that Abeta-42 assembles into stable oligomers that get incorporated into membranes as pores, causing neurotoxicity (Serra-Batiste et al., 2016)

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