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Lower concentrations of GABA have been observed in major depression and post-traumatic stress disorder in the brain, and a region of the brain known as the insular cortex that is associated with emotional response.* Lower insula levels of GABA are associated with a significantly higher trait and state anxiety.* GABA, as an inhibitory neurotransmitter, is one of the mediators responsible for reducing the response to fear or anxiety-provoking stimuli.*

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They trigger the activation of adaptive response signaling pathways and, consequently, defense response to various stressors, increasing the resilience and survival of organisms (Figure 4)

[DOI] [PubMed] [Google Scholar] 346.Jin K., Minami M., Lan J.Q., Mao X.O., Batteur S., Simon R.P., Greenberg D.A