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Vitamin B12 plays a critical role in the bodys energy production, but its deficiency can lead to a host of debilitating symptoms, including tiredness, brain fog, and muscle weakness
Therefore, biosynthesis and metabolism of VD are under the control of VD regulatory genes (GC/ VDBP /VD-25-hydroxylase) in the liver, while the downstream actions of the active 1,25(OH) 2 VD in muscle are mediated by glucose metabolism genes ( VDR /peroxisome proliferator-activated receptor gamma coactivator 1-alpha [ PGC-1 ]/glucose transporter type 4 [ GLUT-4 ])
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Additionally, the redox couple can scavenge radicals, as two glutathione thiyl radicals react to form GSSG ( de novo synthesis, GSH degradation and metabolism, the uptake and export of GSH and GSSG and the efficient reduction of GSSG
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