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What does the evidence indicate regarding the efficacy and safety of oral glutathione supplementation in healthy adults?

Expectedly, depletion of cystine or inhibition of the Xc- antiporter using synthetic small molecule inhibitors including erastin, sulfasalazine, sorafenib and even excess of glutamate triggered cystine depletion, decreased GSH level and reduced GPX4 activity, culminating in ferroptosis induction

, Michelle Cardel, PhD, MS, RD, FTOS , Nick Finer , John Batsis, MD , Stuart Phillips , Derek Miketinas, PhD, RD , Louis Aronne , Kathryn Kaiser, Ph.D

Dirven HA, Dictus EL, Broeders NL, van Ommen B, van Bladeren PJ