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Betaine deficiency has been linked with diabetes, metabolic syndrome, dyslipidemia, and cardiovascular risk factors (Lever and Slow, 2010)

Moreover, genome-wide association studies (GWAS) across different ethnic groups have identified polymorphisms in over 70 non-HLA loci, some of which include key protein-encoding genes that have been shown to play an immune-associated function ( Figure 1 ) (56, 67, 68)