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This situation occurs in chronic diseases such as hypertension, ischemic heart disease, and atherosclerosis 3,8,73

Novoa LJ, Nagra RM, Nakawatase T, et al

Cytokine accumulation in osteitis fibrosa of renal osteodystrophy

SchisandrinB may be responsible for controlling STAT3 upstream proteins (SOCS, PIAS, PTPs) which in turn may cause autophagy triggered by STAT3 signaling activation (185)