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AGEs are final, permanent products of glycation that can modify the physicochemical properties of proteins, increase their resistance to proteolysis, and interact with RAGE receptors, causing oxidative stress and an inflammatory response 57

Contributing factors may include female age, anatomical and chromosomal irregularities, genetic predispositions, endocrinological issues, placental abnormalities, infections, lifestyle choices such as smoking and alcohol use, psychological influences, and exposure to environmental hazards like heavy metals, pollution, and radiation ( Despite ongoing research, the underlying causes of RM remain elusive, hindering effective treatment options and adding to the emotional burden on patients

Interactions with Medications Silymarin may interact with various medications through its influence on cytochrome P450 (CYP450) enzymes