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Notably, there was a significant upregulation in the mRNA expression of immune-related genes, including TLR1 , TLR2 , TLR3 , TLR4 , TLR5 , TLR7 , TLR15 , MHC I , MHC II , and MyD88 at various time intervals

doi: 10.3389/fpls.2022.958490 Received 31 May 2022 Accepted 27 July 2022 Published 16 August 2022 Volume 13 - 2022 Edited by Cecilia Gotor, Institute of Plant Biochemistry and Photosynthesis (CSIC), Spain Reviewed by Mirko Zaffagnini, University of Bologna, Italy

This clustering of disorders is often due to shared genetic susceptibility, allowing multiple autoimmune diseases to arise in a single individual

Alternatively, the vascular theory posits optic nerve head atrophy due to insufficient blood supply leading to RGC injury [400]