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The Ames Salmonella mammalian microsome mutagenicity test (209) was used in recent research to determine the mutagenicity of dimethylglycine incubated with nitrites under conditions that resembled long-term human ingestion (210)

In some embodiments, the otic formulation or composition comprises between about 0.01% to about 10% by weight of the poloxamer

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9 The diagnostic approach provided by Rutter directly influenced the revision of DSM-III