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Acyl-CoA synthetase long-chain family member 4 (ACSL4) catalyzes the activation of PUFAs, while lysophosphatidylcholine acyltransferase 3 (LPCAT3) precisely incorporates them into the sn-2 position of membrane phospholipids (e.g., phosphatidylethanolamine)

Lifestyle changes for MCAS: Low-histamine Diet: Allergy elimination diets and low-histamine diets have been shown in studies to be helpful to some people with chronic itching (one symptom of MCAS)

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