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Peer review Peer review information Nature Communications thanks Gawain McColl, Jie Zhao and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

The unbalanced interaction between oxidants and antioxidants has an impact on reproductive pathologies such as abnormalities in oocyte metabolism endometrial maturation through the activation of nuclear factor-kappa B (NF-) and nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant signaling pathways, endometriosis, polycystic ovarian syndrome (PCOS), infertility, prenatal development disorders, and complications

So, did a quick query on Google Gemini Pro to get a quick overview (not wanting to that long document until I knew a little more): FOXO4-DRI Current scientific consensus as of 2026 characterizes FOXO4-DRI (D-Retro-Inverso) as a potent experimental senolytic peptide with robust preclinical evidence but limited clinical validation

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