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Increasing type-IV collagen-mediated signaling drastically increases metastases in multiple tumor types, especially those with markedly higher IGF1R expression levels (Lalonde et al., 2014)

If this does happen, the recommendation is to stop taking ALC, due to lack of studies on its effects during pregnancy

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Furthermore, ASCT2 (SLC1A5) is expressed in higher levels than ASCT1 in the mouse BBB and it was localized at the abluminal side by immunohistochemical analysis (Tetsuka et al., 2003