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Metabolites were identified and quantified using liquid chromatographymass spectrometry (LC-MS)

Providers should transition to emerging weight loss peptides when a patient experiences intractable side effects (like severe nausea or gastroparesis), when they hit a hard weight loss plateau despite dietary compliance, or when the primary clinical obstacle is documented cellular metabolic resistance rather than hyperphagia (overeating)

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Pre-publication history The pre-publication history for this paper can be accessed here: Additional information Competing interests The authors declare that they have no competing interests