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Glutathione levels decline with age, chronic illness, high oxidative load (alcohol, medications, pollution, chronic stress), and acute illness

( Reference Lawler, Barnes and Wu 34 ) demonstrated a direct doseresponse relationship of creatine concentration with superoxide anion (O 2 ), peroxynitrite (OONO ) and 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) as determined by the rate of renewal of the ABTS + radical, and concluded that creatine has a significant role as an antioxidant