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High levels of uric acid can be a key regulator for oxidative stress (21,35)

bFGF, which is one of the 22 different isotypes of FGF, plays a crucial role in the wound healing process by promoting fibroblast proliferation, inducing neovascularization, and increasing the synthesis of collagenase.3033 As the topical administration of human recombinant bFGF has been shown to be effective for wound healing in clinical situations, we selected bFGF as a positive reagent in this study

We believe the improved functional recovery with G-CSF administration in the present study was possibly due to a combination of above processes

Together, the imbalance between proliferative signals and apoptotic resistance drives the persistence and uncontrolled growth of altered cells