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The 5mg + 5mg formulation provides balanced concentrations of both components, allowing for investigation of equipotent effects and optimal ratios for research applications

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Ethics declarations Ethics approval and consent to participate The study protocol was approved by the ethics committee of the Iran University of Medical Sciences (IUMS) in accordance with the World Medical Associations code of ethics (Declaration of Helsinki, revised in Brazil 2013)

Older adults with mild cognitive impairment took NR for 8 weeks and showed lower pTau217 levels - a key marker for Alzheimer's disease [26]