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INTRODUCTION Glutathione (GSH), the major intracellular thiol compound, is a ubiquitous tripeptide produced by most mammalian cells and it is the main mechanism of antioxidant defense against reactive oxygen species (ROS) and electrophiles

Thus, the FDA has approved these two low-intensity DOACs for this indication

These statements do not imply or establish safety, efficacy, bioavailability, or appropriateness for administration outside of controlled laboratory settings

An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways