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Chemical structures of lipoic acid and lipoyllysine residue The figure illustrates the chemical structures of lipoic acid in its oxidized and reduced forms, its two enantiomers ( R - and S -lipoic acid), and its covalent attachment to a lysine residue of the E2 component of the -ketoacid dehydrogenase complex (and the H protein of the glycine cleavage system), forming a lipoyllysine moiety

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LGS may involve imbalances in gut microbiota

These data indicated that renal tubule-specific deletion of Fsp1 promoted ferroptosis and aggravated oxalate-induced AKI