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However, in practice, doseresponse patterns are significantly complicated due to many other interactions with (i) multiple targets (receptors) of different affinities to the active compound, (ii) other regulatory proteins or mediators in the networks involved in the adaptive stress response, (iii) feedback down regulations in the molecular signaling pathways, and/or (iv) metabolic transformation of active ligands into metabolites, a secondary ligand, which have different affinities to various receptors of the adaptive stress response [69]

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Inflammopharmacology 14:214221 Sikiric P, Seiwerth S, Brcic L et al (2010) Revised Roberts cytoprotection and adaptive cytoprotection and stable gastric pentadecapeptide BPC 157

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