The anatomical characteristics of the ACL are critical in determining its ability to resist forces and maintain knee stability
In male Nrf2 -/- knockout mice, there was a reduction in gene expression levels of antioxidant enzymes in the testis and epididymis, including catalytic glutamate cysteine ligase ( Gclc ), glutamate cysteine ligase modifying subunit ( Gclm ) the rate-limiting enzyme in GSH synthesis glutathione transferase m1 ( Gstm1 ), Gstm2 , Gsta3 , and Sod2 , as well as a depletion in GSH concentration and GPX activity compared to wild-type males
Zhang L, Hobeika CS, Khabibullin D, Yu D, Filippakis H, Alchoueiry M, et al
(In some cases, testing reverse T3 may also be helpful, although its not always necessary.) In the case that your T3 is low, or in the bottom part of the reference range, or if youre still symptomatic with T4 medications alone, you may benefit from adding a T3-containing medication such as Cytomel (liothyronine) to your current medication regimen, or switching to a T4/T3 combination medication such as Armour Thyroid* or compounded T4/T3
