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Both agents continued to induce -SMA expression, collagen transcription, and ERK1/2 activation, with similar dynamics as in wild-type cells

Age-related conditionssuch as Alzheimer's diseaseare associated with impaired synaptic plasticity mechanisms, suggesting that maintaining robust homosynaptic plasticity might protect cognitive function

Although measures to study insulin secretion were not performed, this study suggested that even in the context of uncontrolled acromegaly and insulin resistance, insulin still plays a key role in the regulation of circulating IGF-I levels