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In addition, ApoE4 prompts tau-mediated neurotoxicity through its interaction with the vesicular monoamine transporter 2 (VMAT2), thereby impeding the transport of neurotransmitters into synaptic vesicles and ultimately leading to the degeneration of the locus coeruleus (Therriault et al., 2020)

Therefore, HO-1, as a key factor in the inflammatory response, is expected to provide effective strategies for the prevention and treatment of diabetic complications and can provide novel ideas and drug targets for the prevention and treatment of clinical diseases

For the skin penetration study, the dorsal skin of each mouse was cleaned using an alcohol pad, and 14 mg of cream containing 0.2% FITC-GHK, FITC-RGD-GHK, or FITC-sOtx2-GHK peptides were smeared uniformly on the skin (1 cm 2 )

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