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The American Academy of Family Physicians and NIH identify the following clinical manifestations: Fatigue and generalized weakness Megaloblastic anemia (abnormally large, immature red blood cells) Tingling or numbness in the hands and feet (peripheral neuropathy) Difficulty walking and balance problems Cognitive disturbances including memory difficulty and confusion Mood changes, including depression and irritability Glossitis (swollen, inflamed tongue) Early symptoms such as fatigue and mild tingling are often attributed to stress, aging, or other conditions

Coleman, Therapy-induced senescence: opportunities to improve anticancer therapy

Nonetheless, it is necessary to note that enthusiasm about the peptide is always tempered by science

Small Fiber Neuropathy (SFN) SFN is notoriously difficult to diagnose and treat