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GLP-1 Receptor Agonists and the Risk of Fragility Fractures in Older Adults with Type 2 Diabetes

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182,183 Moreover, physcion and its derivative S3, novel small-molecule PGD inhibitors which fits in a pocket of PGD near the binding site of 6-PG to inhibit PGD enzyme activity and then decrease the NADPH level, exhibit excellent anticancer effects and sensitize leukemia cells to antimalarial agent dihydroartemisinin (DHA)

Additionally, visceral adipose tissue releases significant inflammatory and immune mediators (143), stimulating the ovaries and adrenal glands to secrete these hormones (154)