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Intracellular ROS probe DCFH-DA confirmed that E

NCBI National Center for Biotechnology Information Search 3GRS: REFINED STRUCTURE OF GLUTATHIONE REDUCTASE AT 1.54 ANGSTROMS RESOLUTION PDB ID: 3GRS Download MMDB ID: 58319 PDB Deposition Date: 1988/2/5 Updated in MMDB: 2011/10 Experimental Method: x-ray diffraction Resolution: 1.54 Source Organism: Homo sapiens Similar Structures: VAST+ Download sequence data Biological Unit for 3GRS: dimeric

This indicates the existence of a GGCT-mediated Gln metabolic shunt in tumor cells: Gln is prioritized for conversion to GSH, which scavenges ROS, alleviates oxidative stress, and ultimately promotes tumor cell proliferation

Glycine Glycine (Gly) is another essential amino acid in the synthesis of GSH