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Throughout the 0-32 week treatment period, adverse outcomes and the occurrence of anti-cagrillintide antibodies were assessed in addition to any changes in systolic and diastolic blood pressure, pulse rate, plasma high-sensitivity C-reactive protein, aldosterone, and the activity of renin

in this form it is essential for conversion of methylmalonate to succinate and synthesis of methionine from homocysteine (a reaction which also requires folate)