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Hypoxia-inducible Factor Prolyl Hydroxylases as Targets for Neuroprotection by "antioxidant" Metal Chelators: From Ferroptosis to Stroke

The protein thioredoxin, together with TXNRD1 (or TXNRD3), NADPH, and FAD, constitute the thioredoxin antioxidant system involved in the reduction of antioxidant enzymes (e.g., peroxiredoxins, methionine sulfoxide reductases, and ribonucleotide reductase) and of many oxidation/reduction (redox)-sensitive signaling proteins (9)

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Rhodiola rosea and ashwagandha are two such adaptogens