Mitochondrial-derived peptides in health and disease
When tested in a mouse model, rosmarinic acid(RA), a polyphenol found in Lamiaceae herbs, showed that it inhibits the accumulation of phosphorylated tau protein and improves spatial memory ( Curcumin, a primary component of the Indian spice turmeric, has been shown to have an inhibitory effect on tau aggregation with a reduction in tau oligomer ( Tau-protein clearance is increased by treatment with vaccines or antibodies, and multiple clinical trials for tauopathies are currently testing this approach ( A multicenter phase-1b/2a study is being conducted to evaluate the safety and immunogenicity of this vaccine in Alzheimers disease (AD) patients(NCT04445831).BIIB092 is a humanized monoclonal antibody developed against an N-terminal fragment of tau (extracellular tau) secreted from familiar AD-patient-derived pluripotent stem cells
Bacteriostatic water and all peptides referenced here, including those sold by Flex Peptides (flexpeptides.co.uk), are not approved by the MHRA, FDA, or any other regulatory body for human or veterinary use, diagnosis, treatment, cure, or prevention of any disease or condition
Analysis of long-term function and survival of edaravone oral suspension-treated patients with amyotrophic lateral sclerosis using PRO-ACT data as historical placebo controls
