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Apomorphine activates central dopamine pathways, while three PDE5 inhibitors cover fast onset, long duration, and high selectivity

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It is added because it addresses two specific and significant clinical problems that arise from GLP-1 receptor agonist therapy: nausea at treatment initiation and progressive B12 depletion over the course of long-term use

ECG Recording ECGs were recorded continuously in deeply anesthetized rats for all three main leads, by positioning stainless steel electrodes on all four limbs using an ECG monitor with a 2090 programmer (Medtronic, Minneapolis, MN, USA) connected to a Waverunner LT342 digital oscilloscope (LeCroy, Chestnut Ridge, NY, USA) at 15 min, 24 h or 48 h ligation-time