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When a precursor protein fold or import process is defective, the proteins may accumulate on the OMM or on the TOM complex, affecting normal protein entry into mitochondria and resulting in cell stress as well as damage [43]

The performance of the mannitol excretion test in other disease conditions and treatments will need to be evaluated and compared against the multitude of studies using a combined assessment of lactulose and mannitol excretion (13)

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