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*Correspondence: Antonio Di Sabatino, [email protected] This article was submitted to Gastroenterology, a section of the journal Frontiers in Medicine Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

When tumor cells are detached from the ECM, glucose metabolism and mitochondrial respiration are inhibited, leading to reduced cellular energy synthesis and increased intracellular ROS levels, indicating the important role of ECM adhesion in cellular metabolism (125)

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