alpha lipoic acid and l-carnitine Spring Valley Acetyl HCl Dietary Supplement, 50 Count HSA/FSA Eligible Acetyl L-Carnitine 400 mg with

Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)

S2CID 1929961

In its reduced form, it helps neutralize peroxides, thanks to its free thiol group

Zhang W, Konopleva M, McQueen T, Schober W, Andreeff M