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Studies (Guo et al., 2023) have shown that the incidence of depression in females is approximately 4.27 times higher than in males, which may be related to psychosocial stress, hormonal fluctuations, and physiological factors

In general, TriMix is commonly shipped on ice, stored frozen until first use, and then kept under refrigeration after first use

Most trials run for a few years in higher-risk patients, not decades in low-risk ones, so their reassurance does not automatically extend to 30+ years of treatment in a younger, healthier population

We describe these as areas of potential support, not promises, and we set expectations clearly before anyone begins