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By systematically reviewing and synthesizing existing literature, this article aims to provide insights for further investigation into ferroptosis mechanisms in OA and to broaden potential therapeutic targets and approaches for clinical management of ferroptosis-related pathological processes

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Coronal T2-weighted (T2W) MRI scans (2D TurboRAGE) of the whole brain were performed with a vertical-bore 9.4 T Bruker AVANCE 400WB imaging spectrometer with a 250 mTm 1 actively shielded imaging gradient insert (Bruker BioSpin, Billerica, MA) controlled by Paravision software